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  • Cilia and Nervous System Development and Function

    Series series Biomedical and Life Sciences (R0)
    Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more ... Read more

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    Series series Biomedical and Life Sciences (R0)
    This book, written by one of the leaders in the field of the neurosciences, will give an explanation of the symptoms and eventual untimely suicide of one of literatures greatest authors; Virginia Woolf. The sources used are letters and statements from Woolf herself, the literature she wrote and comments, letters and any other documentation that referred to her mental state and her medical status. ... Read more

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  • Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)

    Series series Biomedical and Life Sciences (R0)
    Phosphatases, such as TNAP are fundamental in regulating the roles of cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity. Regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral ... Read more

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  • The Cadherin Superfamily

    Key Regulators of Animal Development and Physiology

    Series series Biomedical and Life Sciences (R0)
    This book presents an overview of the entire field of cadherin research and provides the current basic concept of cadherins. Cadherins have been widely accepted as key regulators of animal development and physiological functions, and it also has become clear that they play essential roles in various human diseases. With contributions by leading scientists, the book covers various aspects of the ... Read more

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  • Oxygen Homeostasis and Its Dynamics

    Series series Medicine (R0)
    This first volume in a projected series contains the proceedings of the first of the Keio University International Symposia for Life Sciences and Medicine under the sponsorship of the Keio University Medical Science Fund. As stated in the address by the President of Keio University at the opening of the 1996 symposium, the fund of Dr. Mitsunada Sakaguchi. The Keio was established by the generous ... Read more

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  • Microglia in the Regenerating and Degenerating Central Nervous System

    Edited by Wolfgang J. Streit ...
    Over the past decade, the study of microglial cells has gained increasing importance, in particular for those working in the fields of degeneration and regeneration. Microglia in the Regenerating and Degenerating CNS supports the assertion that understanding microglial biology could perhaps be pivotal for unraveling the pathogenetic mechanisms that underlie Alzheimer's disease, currently the most ... Read more

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  • Oxidative Neural Injury

    Edited by Sigrid C. Veasey ...
    Series series Biomedical and Life Sciences (R0)
    Twenty-five years ago, Earl R. Stadtman, PhD discovered that specific enzymes regulating metabolism can be inactivated by oxidation [1]. He later showed that age-related oxidative modification contributes, at least in part, to age-related loss of function of the enzymes [2, 3]. Dr. Stadtman broke the ground for a new field of study to discover how oxidative stress contributes in significant ways ... Read more

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  • Translational Research in Environmental and Occupational Stress

    Series series Biomedical and Life Sciences (R0)
    Cutting edge technologies can propel a simple finding in basic science to a concept that can be of immense value to the society. While applying novel techniques to unravel the mysteries of biological processes, an offshoot of applied branch emerged. This field, which is now widely referred to as Translational Research utilizes basic science findings and translates these findings into innovative ... Read more

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  • Gasotransmitters: Physiology and Pathophysiology

    Series series Biomedical and Life Sciences (R0)
    Since the epochal discovery of the radical and highly toxic gas nitric oxide (NO) as a signaling molecule, two other no less toxic gases – carbon monoxide (CO) and hydrogen sulfide (H2S) – have been found to also be involved in a plethora of physiological and pathophysiological functions. The gases termed gasotransmitters play an increasingly important role in understanding how signalling into and ... Read more

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  • Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases

    Edited by Farid Rahimi, Gal Bitan ...
    Series series Biomedical and Life Sciences (R0)
    Amyloid-forming proteins are implicated in over 30 human diseases. The proteins involved in each disease have unrelated sequences and dissimilar native structures, but they all undergo conformational alterations to form fibrillar polymers. The fibrillar assemblies accumulate progressively into disease-specific lesions in vivo. Substantial evidence suggests these lesions are the end state of ... Read more

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  • Behavioral Neurobiology of Aging

    Series series Biomedical and Life Sciences (R0)
    This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. ... Read more

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  • Ontogeny and Phylogeny of the Vertebrate Heart

    Edited by David Sedmera, Tobias Wang ...
    Series series Biomedical and Life Sciences (R0)
    This collection of reviews will be of considerable interests to biologists and MDs working on any aspect of cardiovascular function. With state-of-the-art reviews written by competent experts in the field, the content is also of interest for MSc and PhD students in most fields of cardiovascular physiology. ... Read more

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