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« james m willard »

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  • Lysosomes

    Biology, Diseases, and Therapeutics

    Modifié par Frederick R. Maxfield, James M. Willard, Shuyan Lu ...
    Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development.• Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug ... En savoir plus

    $209.99 CAD

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  • Principles of Clinical Pharmacology

    Modifié par Darrell R. Abernethy, Charles E. Daniels, Robert Dedrick, Sanford P. Markey, Arthur J. Atkinson Jr. ...
    This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic ... En savoir plus

    $113.99 CAD

  • New Strategies in Stroke Intervention

    Ionic Transporters, Pumps, and New Channels

    Modifié par Lucio Annunziato ...
    Collections series Biomedical and Life Sciences (R0)
    Ischemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system. To date, few effective therapies have been realized. Recent evidence, however, suggests that channels, pumps, and ionic exchangers are involved in CNS ischemia and ischemic stroke, but the potential contribution of these channels for ... En savoir plus

    $128.99 CAD

  • Phosphodiesterase Inhibitors

    par Christian Schudt, Gordon Dent, Klaus F. Rabe, Clive Page ...
    Collections series Handbook of Immunopharmacology
    Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, ... En savoir plus

    $167.99 CAD

  • Novel Cytokine Inhibitors

    Modifié par Brian Henderson, Gerry A. Higgs ...
    Collections series Medicine (R0)
    Cytokines have become established as key mediators of the signs and symptoms of inflammatory diseases such as arthritis, dermatitis, asthma and multiple sclerosis. Furthermore, they are involved in the cascade of events leading to cardiovascular shock and are major regulators of the function of immune cells. This book reviews recent advances in the development of new anti-inflammatory drugs. It ... En savoir plus

    $64.99 CAD

  • Attrition in the Pharmaceutical Industry

    Reasons, Implications, and Pathways Forward

    par Alexander Alex, C. John Harris, Dennis A. Smith ...
    With a focus on case studies of R&D programs in a variety of disease areas, the book highlights fundamental productivity issues the pharmaceutical industry has been facing and explores potential ways of improving research effectiveness and efficiency.Takes a comprehensive and holistic approach to the problems and potential solutions to drug compound attritionTackles a problem that adds billions of ... En savoir plus

    $160.99 CAD

  • Regenerative Pharmacology

    Modifié par Karl-Erik Andersson, George J. Christ ...
    Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental and molecular biology; chemical and material sciences (i.e. nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As ... En savoir plus

    $109.99 CAD

  • Preventive and Predictive Genetics: Towards Personalised Medicine

    Modifié par Godfrey Grech, Iris Grossman ...
    Collections series Medicine (R0)
    Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine ... En savoir plus

    $179.39 CAD

  • Connexins

    A Guide

    Modifié par Andrew Harris, Darren Locke ...
    Connexins: A Guide is a practical and valuable reference and text covering a wide scope of information about the connexin family of membrane channel proteins. The editors and contributing authors intend for this cutting-edge work to be informative to scientists wishing to learn about the field, as well as to those who are active researchers in this area. Connexins: A Guide masterfully addresses ... En savoir plus

    $128.99 CAD

  • High Throughput Screening for Novel Anti-Inflammatories

    Modifié par Michael Kahn ...
    Collections series Progress in Inflammation Research
    Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much to learn about the integration of these powerful techniques with information from genomics, proteomics, computation and pharmacokinetics before dramatic increases in the drug discovery/development processes can be achieved. The chapters in this book represent ... En savoir plus

    $179.99 CAD

  • Oral Delivery of Macromolecular Drugs

    Barriers, Strategies and Future Trends

    Modifié par Andreas Bernkop-Schnürch ...
    Recent and rapid progress in the field of biotechnology has resulted in an increasing number of novel macromolecular drugs with great promise for further advanced research and clinical application. However, the delivery of these macromolecular drugs by routes other than the parenteral route is difficult. The pipeline of macromolecular drugs derived from biotechnology presents a challenging ... En savoir plus

    $179.99 CAD

  • Tactics in Contemporary Drug Design

    Modifié par Nicholas A. Meanwell ...
    Collections series Chemistry and Material Science (R0)
    Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. ... En savoir plus

    $192.99 CAD