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« leonard guarente »

1-12 sur 12 résultats pour « leonard guarente »
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  • Introductory Review on Sirtuins in Biology, Aging, and Disease

    Modifié par Leonard Guarente, Raul Mostoslavsky, Aleksey Kazantsev ...
    Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several ... En savoir plus

    $113.99 CAD

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  • Nutrition in Epigenetics

    Modifié par Mihai D. Niculescu, Paul Haggarty ...
    The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics ... En savoir plus

    $280.99 CAD

  • DNA Repair in Cancer Therapy

    Molecular Targets and Clinical Applications

    Modifié par Mark R. Kelley ...
    Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle, and current treatments, which typically include radiotherapy, chemotherapy and surgery, are not often enough to rid the patient of his or her cancer. Cancer cells can become resistant to the treatments directed at them, ... En savoir plus

    $121.99 CAD

  • Metabolism of Drugs and Other Xenobiotics

    Modifié par Pavel Anzenbacher, Ulrich M. Zanger ...
    A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook providessystematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviewsthe main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover ... En savoir plus

    $285.99 CAD

  • The Heterogeneity of Cancer Metabolism

    Modifié par Anne Le ...
    Collections Livre 1311 - Advances in Experimental Medicine and Biology
    This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field.Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and ... En savoir plus

    Gratuit

  • Pharmacogenomics of Human Drug Transporters

    Clinical Impacts

    par Toshihisa Ishikawa, Richard B. Kim, Jörg König ...
    Sets the foundation for safer, more effective drug therapiesWith this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse ... En savoir plus

    $191.99 CAD

  • DNA Repair of Cancer Stem Cells

    Modifié par Elain Hurt, Stephanie M Cabarcas, Lesley A Mathews ...
    Collections series Biomedical and Life Sciences (R0)
    The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, ... En savoir plus

    $179.99 CAD

  • Mitochondria and Cancer

    Modifié par Keshav Singh, Leslie Costello ...
    Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration ... En savoir plus

    $179.99 CAD

  • Protein Oxidation and Aging

    par Tilman Grune, Betul Catalgol, Tobias Jung, Vladimir Uversky ...
    Collections Livre 15 - Wiley Series in Protein and Peptide Science
    Reviews our current understanding of the role of protein oxidation in aging and age-related diseasesProtein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently by exploring the aging process and developing more effective therapies to prevent or treat age-related diseases. There have been many studies ... En savoir plus

    $197.99 CAD

  • The DNA Damage Response: Implications on Cancer Formation and Treatment

    Modifié par Yosef Shiloh, Kum Kum Khanna ...
    Collections series Biomedical and Life Sciences (R0)
    The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living ... En savoir plus

    $179.99 CAD

  • EBNA1 and Epstein-Barr Virus Associated Tumours

    par Lori Frappier ...
    Collections series Biomedical and Life Sciences (R0)
    This SpringerBrief is comprehensive account of the functions and effects of the Epstein-Barr virus (EBV) EBNA1 protein that relate to EBV-associated cancers and evidence for EBNA1 contributions to these cancers. EBNA1 was the first EBV protein detected and the most critical for EBV latent infection. EBNA1 fulfills multiple functions at EBV genomes which have been described in many (sometimes ... En savoir plus

    $64.09 CAD

  • Telomeres, Diet and Human Disease

    Advances and Therapeutic Opportunities

    Modifié par Amelia Marti, Guillermo Zalba ...
    The maintenance of telomeres—repetitive sequences at the end of chromosome—is essential to health. Dysfunction in telomere maintenance pathways plays a role in aging, cancer, atherosclerosis and other diseases. This has led to telomere maintenance as a prime target for patient therapies. This book describes the advances in telomere research as it applies to human health and especially how ... En savoir plus

    $97.55 CAD