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  • Single Nucleotide Polymorphisms

    Human Variation and a Coming Revolution in Biology and Medicine

    Collections series Biomedical and Life Sciences (R0)
    This book explores the importance of Single Nucleotide Polymorphisms (SNPs) in biomedical research. As SNP technologies have evolved from labor intensive, expensive, time-consuming processes to relatively inexpensive methods, SNP discovery has exploded. In terms of human biology, this research, particularly since the completion of the Human Genome Project, has provided a detailed understanding of ... En savoir plus

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  • Protein Therapeutics

    Collections series Chemistry and Material Science (R0)
    Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. ... En savoir plus

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    This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against ... En savoir plus

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    Complex Systems in Human Disease and Therapeutics

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  • Handbook of Cell Signaling, Three-Volume Set

    Collections series Cell Biology
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  • Epigenetics in Cancer

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    Collections series Life Science Research Fundamentals
    Epigenetics is the study of heritable changes in gene expression or cellular phenotype, caused by mechanisms other than changes in the DNA sequence. Examples include DNA methylation and histone modification. These changes may remain through cell divisions and multiple generations. Epigenetic differences among individuals may account for some of the differences between monozygotic (identical) twins ... En savoir plus

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  • Epigenetic Regulation and Epigenomics

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    Collections series Advances in Molecular Biology and Medicine
    Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused ... En savoir plus

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