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  • Oxidative Stress and Free Radical Damage in Neurology

    Modifié par Natan Gadoth, Hans Hilmar Göbel ...
    Collections series Biomedical and Life Sciences (R0)
    The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with ... En savoir plus

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    Modifié par Ben A. Oostra ...
    Collections series Biomedical and Life Sciences (R0)
    Till recently, mutations in genes were described in textbooks as deletions or point mutations. These mutations can be inherited from a parent or they are de novo alterations. The discovery in 1991 that human disease can be caused by large-scale ex pansion of highly unstable trinucleotide repeats has elucidated a new mutation mechanism, heritable unstable DNA. In the subsequent years more then 10 ... En savoir plus

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  • Estrogen — Mystery Drug for the Brain?

    The Neuroprotective Activities of the Female Sex Hormone

    par Christian Behl ...
    It is well known that estrogen is "somehow” a protective hormone for various age-related disorders. This book provides a solid knowledge of estrogen’s neuroprotective activities in the brain with a special emphasis on neurodegenerative disorders such as Alzheimer’s Disease. The focus is (1) to describe the biochemical, molecular, and cellular basis of the protective activity of estrogen and (2) to ... En savoir plus

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  • Angiogenesis Modulations in Health and Disease

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    Modifié par Paul J. Davis, Shaker A. Mousa ...
    Collections series Biomedical and Life Sciences (R0)
    This book is a major update of novel targets in angiogenesis modulation, including pro- and anti-angiogenesis. There is in-depth coverage of preclinical and clinical methods and models, investigational status, and clinical applications. The impact of nanotechnology in advancing the applications of pro-and anti-angiogenesis strategies is also highlighted, along with stem cell and biotechnologies in ... En savoir plus

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  • Folding for the Synapse

    Collections series Biomedical and Life Sciences (R0)
    Folding for the Synapse addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of protein dynamics when functioning physiologically as an ... En savoir plus

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  • Perspectives of Stem Cells

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    Collections series Biomedical and Life Sciences (R0)
    Stem cells are fascinating cell types. They can replicate themselves forever while retaining the potential to generate progeny with speci?c functions. Because of these special properties, stem cells have been subjects of intensive investigation, from understanding basic mechanisms underlying tissue generation, to modeling human diseases, to application for cell replacement therapy. Stem cells come ... En savoir plus

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  • Calcium Signaling

    Modifié par Md. Shahidul Islam ...
    Collections series Biomedical and Life Sciences (R0)
    Calcium signaling contains a unique selection of chapters that cover a wide range of contemporary topics in this ubiquitous and diverse system of cell signaling. This book has the flavor of a primary text book, but it is much more than that. It covers topics ranging from the fundamental aspects of calcium signaling to its clinical implications, in a thoughtful and comprehensive way. It discusses ... En savoir plus

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  • Reviews of Physiology, Biochemistry and Pharmacology

    Collections series Biomedical and Life Sciences (R0)
    Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields. ... En savoir plus

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  • The Neuropilins: Role and Function in Health and Disease

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    This book covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer and various eye diseases.The two neuropilin genes encode scaffold receptors that can bind several ... En savoir plus

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  • Phospholipases in Health and Disease

    Collections series Biomedical and Life Sciences (R0)
    Phospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the ... En savoir plus

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  • 5-HT4 Receptors in the Brain and Periphery

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    This book provides a comprehensive, up-to-date review of the distribution, pharmacology and physiology of central 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes exhibit a unique pharmacology, distribution and function, of which the 5-HT4 receptor has been one of the most intensively studied in recent years, both from a basic research standpoint and as a target for novel ... En savoir plus

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